Xeno-free hPL. No trade offs.

Only Heparin-Free Human Platelet Lysate That Is Not Fibrinogen Depleted

Born in a clinical lab, our products have been used to grow cells for thousands of patients globally in more than 50 Phase I, II, and III clinical trials for more than a decade.

PLTGold® contains all the growth factors and proteins that maximize cell growth without the need to worry about animal-based additives or lot-to-lot variability. Other xeno-free hPLs compromise purity with particulates. With PLTGold® there is no clot formation and no need for heparin.

PLTGold® is unfractionated, meaning it is not fibrinogen-depleted. However, even though no components are removed from the original product, our proprietary methodology for PLTGold® production allows for a clot free product that does not contain or require heparin. It is a truly unique human platelet lysate product.

Available in both clinical and research grades in 27mL, 100mL, 500mL, and 1000mL bottles.

Benefits of PLTGold®

Adipose-derived MSCs increased cell growth
Adipose-derived MSCs increased cell growth
  •  Increased cell growth kinetics (reduced cell doubling time)

  •  100% xeno-free, no heparin required

  •  No precipitates from fibrinogen-depletion

  • Manufactured to reduce lot-to-lot variation

  • Reduced supplementation (5% or less supplementation with PLTGold® compared to 10% or more FBS and Human AB Serum)

  • More cost-effective alternative to serum free media supplements

PLTGold<sup>®</sup> lot-to-lot consistency
PLTGold® lot-to-lot consistency
MSCs growing in suspension in microcarriers
MSCs growing in suspension in microcarriers
  • Great for generating cells in large scale bioreactors

  • Contains growth factors and proteins that maximize cell growth

  • Provides an optimal environment for cell culture and drug discovery

  • Not just for MSCs, but also T cells, Endothelial cells, NK cells, tumor cells, iPSCs, and more!

  • Enhances genetic stability in MSC cultures

  • Master File with the FDA

T cells expanding in media with PLTGold<sup>®</sup>
T cells expanding in media with PLTGold®

Quality Products to Fit Your Needs

All our products are manufactured under cGMP conditions. We do release testing on all manufactured lots and provide a CoA/CoO for each lot. Some of our release testing includes: pH, osmolality, total protein, mycoplasma, sterility, endotoxin, and a proprietary cell growth assay. We also test a panel of growth factors on all lots for internal information only. Mill Creek is ISO 9001:2015 certified.

PLTGold® Research Grade

Manufactured to meet the needs of research and development to ensure an easy transition to clinical manufacturing.

Catalog Offerings

PLTGold® Clinical Grade

For use in cGMP clinical applications. Clinical grade PLTGold® products are further certified to be endotoxin free.

Catalog Offerings

PLTGold®-GI Clinical Grade

Gamma irradiated with a 25-38 kGy validated process to improve viral safety.

Catalog Offerings

Performance of PLTGold® vs Serum Based Products

Time-lapse of Adipose-derived MSCs from day 0 to day 5 of culture (14) - PLTGold

PLTGold® 5% (15) - FBS

FBS 10% (16) - AB Serum

Human AB Serum 5%