Pathogen Reduced Human Platelet Lysate
Platelets used in the production of PLTMax® and PLTGold® were originally obtained for transfusion in humans and therefore meet all the requirements of the FDA and AABB, including testing for transmissible diseases. However, the inherent risk of emerging infectious agents from human blood products remains a concern for the efficient production of large volumes of cells for applications in cell therapy. For that reason, we have developed pathogen inactivated versions of our successful products: PLTMax®-PI and PLTGold®-PI.
PLTMax®-PI and PLTGold®-PI are manufactured with human platelets that have undergone the INTERCEPT® pathogen reduction process, by Cerus Corporation. Using PI products to grow MSCs will yield similar performance to regular PLTMax® and PLTGold®, with an approved pathogen reduction process.
Available in clinical grades in 27mL, 100mL, 500mL, and 1000mL bottles.
Benefits of PLTMax®-PI and PLTGold®-PI
Increased cell growth kinetics (reduced cell doubling time)
Contains growth factors and proteins that maximize cell growth
No precipitates from fibrinogen-depletion
Enhances genetic stability in MSC cultures
Great for generating cells in large scale bioreactors
Manufactured to reduce lot-to-lot variation
Reduced supplementation (5% or less supplementation with PI products compared to 10% or more FBS and Human AB Serum)
More cost-effective alternative to serum free media supplements
Master File with the FDA
Quality Products to Fit Your Needs
All our products are manufactured under cGMP conditions. We do release testing on all manufactured lots and provide a CoA/CoO for each lot. Some of our release testing includes: pH, osmolality, total protein, mycoplasma, sterility, endotoxin, and a proprietary cell growth assay. We also test a panel of growth factors on all lots for internal information only. Mill Creek is ISO 9001:2015 certified.
Performance of PLTGold®-PI
Differentiation of Ad-MSCs expanded in suspension using medium supplemented with PLTGold®: Adipogenesis (Oil-red-O staining), osteogenesis (Alizarin Red staining) and chondrogenesis (Alcian blue staining) shown.
